In Blood Omen, a lake surrounded the home of Elzevir the Dollmaker. This was the Lake of Lost Souls, aptly named considering the dollmaker's hobby. He stole souls and imprisoned them in his creations. Kain visited the lake while trying to reclaim the Princess of Willendorf's soul from the strange little man.
The Lake of Serenity also featured in Blood Omen. It surrounded Willendorf City, and the neighbouring Willendorf township could be reached by crossing a bridge on its east side. The Blood Omen in-game map shows that the lake extended a little further south than is illustrated above.